早搏后增强：钙稳态与心力衰竭之间的联系？
Post-extrasystolic Potentiation: Link between Ca(2+) Homeostasis and Heart Failure?
作者信息
Sprenkeler David J, Vos Marc A
机构信息
University Medical Center Utrecht, Utrecht, The Netherlands.
出版信息
Arrhythm Electrophysiol Rev. 2016 May;5(1):20-6. doi: 10.15420/aer.2015.29.2.
Post-extrasystolic potentiation (PESP) describes the phenomenon of increased contractility of the beat following an extrasystole and has been attributed to changes in Ca(2+) homeostasis. While this effect has long been regarded to be a normal physiological phenomenon, a number of reports describe an enhanced potentiation of the post-extrasystolic beat in heart failure patients. The exact mechanism of this increased PESP is unknown, but disruption of normal Ca(2+) handling in heart failure may be the underlying cause. The use of PESP as a prognostic marker or therapeutic intervention have recently regained new attention, however, the value of the application of PESP in the clinic is still under debate. In this review, the mechanism of PESP with regard to Ca(2+) in the normal and failing heart will be discussed and the possible diagnostic and therapeutic role of this phenomenon will be explored.
期前收缩后增强（PESP）描述了一次期前收缩后紧接着的那次心搏收缩力增强的现象，并且一直被认为与Ca(2+) 稳态的变化有关。虽然这种效应长期以来被视为一种正常的生理现象，但有一些报告描述了心力衰竭患者期前收缩后心搏的增强作用增强。这种增强的PESP的确切机制尚不清楚，但心力衰竭中正常Ca(2+) 处理的破坏可能是根本原因。近期，将PESP用作预后标志物或治疗干预手段再次受到新的关注，然而，PESP在临床应用中的价值仍存在争议。在本综述中，将讨论正常和衰竭心脏中与Ca(2+) 相关的PESP机制，并探讨这一现象可能的诊断和治疗作用。
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