Steger Alexander, Sinnecker Daniel, Barthel Petra, Müller Alexander, Gebhardt Josef, Schmidt Georg
1st Medical Clinic and Policlinic, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Arrhythm Electrophysiol Rev. 2016 May;5(1):27-30. doi: 10.15420/aer.2016.14.2.
For more than 100 years physicians have observed that heartbeats following extrasystolic beats are characterised by augmented myocardial contractility. This phenomenon was termed post-extrasystolic potentiation (PESP). In the 1970s it was first noted that PESP measured at the blood pressure level is typically pronounced in heart failure patients. Only recently, it was shown that PESP measured non-invasively as post-extrasystolic blood pressure potentiation was a strong and independent predictor of death in survivors of myocardial infarction and in patients with chronic heart failure. A similar parameter (PESPAfib) can be also assessed in patients with atrial fibrillation. PESP and PESPAfib can be understood as non-invasive parameters that indicate myocardial dysfunction. They have the potential to improve risk stratification strategies for cardiac patients.
100多年来，医生们观察到，早搏后的心跳具有心肌收缩力增强的特征。这种现象被称为早搏后增强（PESP）。20世纪70年代，人们首次注意到，在血压水平上测量的PESP在心力衰竭患者中通常很明显。直到最近，研究表明，以早搏后血压增强的形式进行无创测量的PESP是心肌梗死幸存者和慢性心力衰竭患者死亡的有力且独立的预测指标。心房颤动患者也可以评估类似的参数（PESPAfib）。PESP和PESPAfib可被理解为指示心肌功能障碍的无创参数。它们有可能改善心脏病患者的风险分层策略。
