室性早搏诱发心肌病的机制及危险因素

Shen Xiaoyu, Zhu Xiyao, Zuo Lingyan, Liu Xu, Qin Mu

Shanghai Jiaotong University, 200030 Shanghai, China.

Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, 200030 Shanghai, China.

Rev Cardiovasc Med. 2023 Dec 15;24(12):353. doi: 10.31083/j.rcm2412353. eCollection 2023 Dec.

Frequent premature ventricular contractions (PVCs) can cause a reversible form of cardiomyopathy in patients without structural heart disease. Because of the challenging nature of PVC-induced cardiomyopathy (PVICM), the mechanisms and risk factors for PVICM are still unclear. Based on the evidence from retrospective and observational studies, the risk factors for the development of PVICM, in addition to PVC exposure, include QRS duration, coupling interval and male sex. Based on animal models, abnormal calcium handling and cardiac remodeling may be the crucial mechanism underlying the development of cardiomyopathy. We have summarized the current knowledge on PVICM in this review. Understanding these mechanisms and risk factors is important for the diagnosis and management of this condition, which can lead to heart failure if left untreated.

频发室性早搏（PVCs）可在无结构性心脏病的患者中导致一种可逆性心肌病。由于PVC诱发的心肌病（PVICM）具有挑战性，PVICM的机制和危险因素仍不清楚。基于回顾性和观察性研究的证据，除了PVC暴露外，PVICM发生的危险因素还包括QRS时限、联律间期和男性性别。基于动物模型，钙处理异常和心脏重塑可能是心肌病发生的关键机制。我们在本综述中总结了目前关于PVICM的知识。了解这些机制和危险因素对于这种疾病的诊断和管理很重要，如果不治疗，这种疾病可能会导致心力衰竭。