正常小鼠天然抗体中功能性独特型网络的证据。
Evidence for a functional idiotypic network among natural antibodies in normal mice.
作者信息
Lundkvist I, Coutinho A, Varela F, Holmberg D
机构信息
Department of Applied Cell and Molecular Biology, University of Umeå, Sweden.
出版信息
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5074-8. doi: 10.1073/pnas.86.13.5074.
We monitored in normal adult BALB/c mice the serum concentrations of four natural IgM antibodies, two of which show idiotypic complementarity in in vitro assays. In each individual, serum concentration of all four idiotypes were found to fluctuate in complex dynamical patterns with low correlation. The spectral power of some such patterns was found to be compatible with the existence of a chaotic regime. Groups of normal adult mice were injected intravenously with low (10 ng) or moderate (10 micrograms) doses of either of the two complementary idiotypes in saline. This treatment resulted in a pronounced inhibition of the fluctuation in the serum concentration of both complementary idiotypes for periods up to 3 months. Such compensations were not detected for the two unrelated natural idiotypes and were specifically induced, for they did not occur following the injection of unrelated antibodies. These results indicate the functional operation of an idiotypic network among natural antibodies.
我们监测了正常成年BALB/c小鼠体内四种天然IgM抗体的血清浓度，其中两种在体外试验中表现出独特型互补性。在每只个体中，发现所有四种独特型的血清浓度都以复杂的动态模式波动，相关性较低。发现某些此类模式的频谱功率与混沌状态的存在相符。将成年正常小鼠分组，静脉注射低剂量（10纳克）或中等剂量（10微克）的两种互补独特型中的任意一种于盐水中。这种处理导致两种互补独特型的血清浓度波动在长达3个月的时间内受到显著抑制。对于两种不相关的天然独特型未检测到此类补偿，且这种补偿是特异性诱导的，因为注射不相关抗体后未出现这种情况。这些结果表明天然抗体之间存在独特型网络的功能运作。
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