正常个体和自身免疫个体中天然抗体的群体动态。
Population dynamics of natural antibodies in normal and autoimmune individuals.
作者信息
Varela F, Andersson A, Dietrich G, Sundblad A, Holmberg D, Kazatchkine M, Coutinho A
机构信息
Centre National de la Recherche Scientifique, Ecole Polytechnique, Paris, France.
出版信息
Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5917-21. doi: 10.1073/pnas.88.13.5917.
Abstract
We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoire, regulating the activation and decay of individual clones. The temporal changes of both disease-specific and nonspecific autoantibodies are consistently modified in autoimmune individuals.
摘要
我们测量了正常、未接受过处理的个体血清中天然存在的自身抗体的数量。这些数量随时间的变化遵循宽带复杂动力学模式，在小鼠和人类中相似。这些模式更有可能反映天然抗体库的网络结构，调节单个克隆的激活和衰减。在自身免疫个体中，疾病特异性和非特异性自身抗体的时间变化均持续改变。
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