Eichelmann F, Schwingshackl L, Fedirko V, Aleksandrova K
Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
Obes Rev. 2016 Nov;17(11):1067-1079. doi: 10.1111/obr.12439. Epub 2016 Jul 13.
Plant-based dietary interventions have been proposed to reduce obesity induced chronic low-grade inflammation and hence prevent chronic disease risk; however, human evidence remains unclear. This systematic review and meta-analysis of intervention trials aimed to assess the effect of plant-based diets on obesity-related inflammatory biomarker profiles. Medline, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for articles published until January 2016 and mean differences in biomarkers of inflammatory status were assessed for: C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-ɑ), soluble intercellular adhesion molecule 1 (sICAM), leptin, adiponectin and resistin. Of initially identified 2,583 publications, 29 met the meta-analysis inclusion criteria [a total of 2,689 participants]. Consumption of plant-based diets was associated with a reduction in the mean concentrations of the following biomarkers: CRP [effect size, -0.55 mg/l, 95% confidence intervals (CI): -0.78; -0.32, I = 94.4%], IL-6 [effect size, -0.25 ng/l, 95% CI: -0.56; 0.06, I = 74%], and, to some degree, sICAM (-25.07 ng/ml [95% CI: -52.32; 2.17, I = 93.2%]). No substantial effects were revealed for TNF-ɑ, resistin, adiponectin and leptin. Plant-based diets are associated with an improvement in obesity-related inflammatory profiles and could provide means for therapy and prevention of chronic disease risk.
基于植物的饮食干预已被提出用于减轻肥胖引起的慢性低度炎症，从而预防慢性病风险；然而，人体研究证据仍不明确。这项对干预试验的系统评价和荟萃分析旨在评估基于植物的饮食对肥胖相关炎症生物标志物谱的影响。检索了Medline、EMBASE和Cochrane对照试验中央注册库（CENTRAL）中截至2016年1月发表的文章，并评估了炎症状态生物标志物的平均差异，这些生物标志物包括：C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、可溶性细胞间黏附分子1（sICAM）、瘦素、脂联素和抵抗素。在最初识别的2583篇出版物中，29篇符合荟萃分析纳入标准（共2689名参与者）。食用基于植物的饮食与以下生物标志物的平均浓度降低有关：CRP[效应量，-0.55mg/l，95%置信区间（CI）：-0.78；-0.32，I²=94.4%]、IL-6[效应量，-0.25ng/l，95%CI：-0.56；0.06，I²=74%]，以及在一定程度上sICAM（-25.07ng/ml[95%CI：-52.32；2.17，I²=93.2%]）。未发现TNF-α、抵抗素、脂联素和瘦素有显著影响。基于植物的饮食与肥胖相关炎症谱的改善有关，并可为慢性病风险的治疗和预防提供方法。
