Rolschau J
Acta Obstet Gynecol Scand Suppl. 1978;72:22-7.
The number of infarctions and intervillous thromboses have been determined in a randomized, optimal obstetric material, consisting of 301 placentae. All the placentae were examined without knowledge of the pregnancies, deliveries or infants. They were examined macroscopically and histologically. The total content of protein, RNA and DNA were determined in a randomized sample of the 301 placentae. Fifty-two placentae had small infarctions, and the corresponding birth weights, placental weights and placental DNA were of the same magnitude as in the remainder of the material. There was the same frequency of infarctions among the placentae with intervillous thrombosis. There were 11 with intervillous thrombosis, and they had a significant reduction in infant birth weight and in placental content of DNA. A significant part of these (6) had asphyxia at birth. In neither of the groups was there proliferation of Langhans cells as a sign of longer lasting anoxia. The extent of villous fibrosis in the groups was the same as in the remainder of the material. It is concluded, that no evidence was found to support a theory that infarctions and intervillous thromboses have the same pathogenesis.
在由301个胎盘组成的随机选取的优质产科样本中，已确定梗死灶数量和绒毛间血栓形成情况。所有胎盘均在不了解妊娠、分娩或婴儿情况的前提下进行检查。对其进行了宏观和组织学检查。在这301个胎盘的随机样本中测定了蛋白质、RNA和DNA的总含量。52个胎盘有小梗死灶，其相应的出生体重、胎盘重量和胎盘DNA与样本其余部分的情况相当。绒毛间血栓形成的胎盘梗死灶发生率相同。有11个存在绒毛间血栓形成，其婴儿出生体重和胎盘DNA含量显著降低。其中相当一部分（6个）出生时存在窒息。两组中均未出现朗汉斯细胞增殖作为持续性缺氧迹象的情况。两组中绒毛纤维化程度与样本其余部分相同。得出的结论是，未发现证据支持梗死灶和绒毛间血栓形成具有相同发病机制这一理论。
