Grygiel-Górniak Bogna, Puszczewicz Mariusz
Department of Rheumatology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Reumatologia. 2015;53(4):207-12. doi: 10.5114/reum.2015.53998. Epub 2015 Sep 21.
Many connective tissue diseases are characterized by fatigue, which is described in the literature as prostration, weakness, lassitude or asthenia. In many other diseases (autoimmune, neurologic or metabolic) fatigue impinges on daily activities and thus influences the quality of life. Different molecular backgrounds are involved in the development of fatigue. Not only does the immunosuppressive treatment of autoimmune diseases reduce fatigue, but also selective nutritional components may have an effect on secretion of cytokines which are responsible for development of the sensation of tiredness (e.g. secretion of interleukin-6). The beneficial influence of selected food components (such as polyunsaturated omega-3 fatty acids, nutritional antioxidants or adequate fat intake with the diet) on proinflammatory cytokine secretion has been demonstrated in many studies. In this review, the biochemical, neurological and nutritional aspects of fatigue in autoimmune diseases are underlined.
许多结缔组织疾病都以疲劳为特征，在文献中，疲劳被描述为虚脱、虚弱、倦怠或乏力。在许多其他疾病（自身免疫性、神经或代谢性疾病）中，疲劳会影响日常活动，进而影响生活质量。疲劳的发生涉及不同的分子背景。自身免疫性疾病的免疫抑制治疗不仅能减轻疲劳，而且某些特定的营养成分可能会对负责产生疲劳感的细胞因子的分泌产生影响（例如白细胞介素-6的分泌）。许多研究已经证实了某些特定食物成分（如多不饱和ω-3脂肪酸、营养抗氧化剂或饮食中适量的脂肪摄入）对促炎细胞因子分泌的有益影响。在这篇综述中，强调了自身免疫性疾病中疲劳的生化、神经学和营养方面。
