Rudroff Thorsten, Workman Craig D, Bryant Andrew D
Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.
Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Brain Sci. 2022 Apr 26;12(5):556. doi: 10.3390/brainsci12050556.
Mortality of acute coronavirus disease (COVID-19) is higher in men than in women. On the contrary, women experience more long-term consequences of the disease, such as fatigue. In this perspective article, we proposed a model of the potential factors that might contribute to the higher incidence of post-COVID-19 fatigue in women. Specifically, psycho-physiological factors are features that might increase central factors (e.g., inflammation) and result in greater perceptions of fatigue. Furthermore, pre-existing conditions likely play a prominent role. This model offers a framework for researchers and clinicians, and future research is required to validate our proposed model and elucidate all mechanisms of the increased incidence and prevalence of post-COVID-19 fatigue in women.
急性冠状病毒病（COVID-19）的死亡率男性高于女性。相反，女性经历该疾病的更多长期后果，如疲劳。在这篇观点文章中，我们提出了一个模型，阐述了可能导致女性COVID-19后疲劳发生率较高的潜在因素。具体而言，心理生理因素可能会增加中枢因素（如炎症），从而导致更强烈的疲劳感。此外，既往疾病可能也起到了重要作用。该模型为研究人员和临床医生提供了一个框架，未来需要开展研究以验证我们提出的模型，并阐明女性COVID-19后疲劳发生率和患病率增加的所有机制。
