安大略省西南部马驹中netF阳性产气荚膜梭菌的患病率。
Prevalence of netF-positive Clostridium perfringens in foals in southwestern Ontario.
作者信息
Finley Abigail, Gohari Iman Mehdizadeh, Parreira Valeria R, Abrahams Miranda, Staempfli Henry R, Prescott John F
机构信息
Department of Pathobiology (Finley, Mehdizadeh Gohari, Parreira, Prescott), Department of Clinical Studies, University of Guelph, Guelph, Ontario (Abrahams, Staempfli).
出版信息
Can J Vet Res. 2016 Jul;80(3):242-4.
NetF-producing Clostridium perfringens have recently been identified as a cause of necrotizing enteritis in neonatal foals, but little is known about its prevalence in clinically normal foals. Foals (n = 88) ranging in age from < 1 wk to 2 to 4 mo (median age 2 to 4 wk) on 8 horse-breeding farms in Ontario were examined on 1 or 2 occasions for the presence of C. perfringens. Of the foals that tested positive, 5 isolates (n = 675) were examined for the netF and enterotoxin (cpe) genes. Colonization by C. perfringens was most marked in foals < 1 wk of age [4.85 ± 2.70 log10 colony-forming units (CFU)] and declined markedly over time (1.23 ± 1.06 log10 CFU at 1 to 2 mo of age). Only 2 isolates possessed the cpe gene and none possessed netF. We concluded that netF-positive C. perfringens does not colonize young foals with any detectable frequency in Ontario and this organism is not likely to be adapted to the intestine of the horse.
最近已确定产生NetF的产气荚膜梭菌是新生马驹坏死性肠炎的病因，但对其在临床正常马驹中的流行情况知之甚少。对安大略省8个养马场中年龄从小于1周龄至2至4月龄（中位年龄2至4周龄）的88匹马驹进行了1次或2次产气荚膜梭菌检测。在检测呈阳性的马驹中，对5株分离株（共675株）进行了netF和肠毒素（cpe）基因检测。产气荚膜梭菌在小于1周龄的马驹中定殖最为明显[4.85±2.70 log10菌落形成单位（CFU）]，并随时间显著下降（1至2月龄时为1.23±1.06 log10 CFU）。仅2株分离株携带cpe基因，无一株携带netF基因。我们得出结论，在安大略省，携带netF基因的产气荚膜梭菌不会以任何可检测到的频率定殖于幼龄马驹，且这种微生物不太可能适应马的肠道。
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