Hitzenberger Christoph K, Drexler Wolfgang, Leitgeb Rainer A, Findl Oliver, Fercher Adolf F
Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna, Austria.
Hanusch Hospital, Vienna, Austria.
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT460-74. doi: 10.1167/iovs.16-19362.
To describe key developments of optical biometry and optical coherence tomography (OCT) for ophthalmic applications made by one of the pioneering research groups.
Partial coherence interferometry (PCI) as the basic ranging technology for modern optical biometry and for OCT was introduced for biomedical applications in the 1980s. Later, Fourier domain (FD) OCT was introduced and demonstrated to provide superior sensitivity as compared to time domain OCT. Further developments comprised ultrahigh-resolution OCT and deep-penetration OCT at wavelengths of approximately 1050 nm. Important functional extensions comprise Doppler OCT/OCT angiography, polarization-sensitive OCT, and adaptive optics OCT.
High-precision PCI biometry has found extensive applications in cataract surgery and in research on intraocular lens design. Optical coherence tomography, especially in the second-generation variant of FD OCT, is now indispensable for ocular diagnostics in general and for retinal diagnostics in particular; 1050 nm OCT shows improved penetration into deeper layers like the choroid.
The contributions of the Vienna research group helped to establish PCI biometry and FD OCT as the gold standards in their respective fields.
描述一个开创性研究团队在眼科应用中光学生物测量和光学相干断层扫描（OCT）的关键进展。
部分相干干涉测量法（PCI）作为现代光学生物测量和OCT的基本测距技术，于20世纪80年代被引入生物医学应用。后来，傅里叶域（FD）OCT被引入，并被证明与时域OCT相比具有更高的灵敏度。进一步的发展包括波长约为1050 nm的超高分辨率OCT和深穿透OCT。重要的功能扩展包括多普勒OCT/OCT血管造影、偏振敏感OCT和自适应光学OCT。
高精度PCI生物测量在白内障手术和人工晶状体设计研究中得到了广泛应用。光学相干断层扫描，尤其是FD OCT的第二代变体，现在对于一般眼科诊断，特别是视网膜诊断来说是不可或缺的；1050 nm OCT对脉络膜等更深层的穿透性有所提高。
维也纳研究团队的贡献有助于将PCI生物测量和FD OCT确立为各自领域的金标准。
