Dr. Christian Weber, LMU Munich - Cardiovascular Prevention, Pettenkoferstr. 9, 80336 Munich, Germany, Tel.: +49 89 4400 54350, Fax: +49 89 4400 54352, E-mail:
Dr. Michael Hristov, LMU Munich - Cardiovascular Prevention, Pettenkoferstr. 9, 80336 Munich, Germany, Tel.: +49 89 4400 54350, Fax: +49 89 4400 54352, E-mail:
Thromb Haemost. 2016 Sep 27;116(4):626-37. doi: 10.1160/TH16-02-0091. Epub 2016 Jul 14.
Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.
单核细胞作为先天免疫系统的细胞，在动脉粥样硬化病变的发展中起着重要作用。越来越多的实验和临床数据表明，血液单核细胞的异质性表明相应亚群对心血管和其他疾病的病理有不同的、特定亚群的贡献，这广泛地得到了认可。本文重新评估了当前的命名法，并总结了单核细胞亚群生物学的关键发现，提出了关于表型、分离和量化各个亚群的共识声明。
