组蛋白变体与植物伴侣蛋白之间的相互作用。

Interplay between histone variants and chaperones in plants.

机构信息

State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, PR China; Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, School of Life Sciences, Fudan University, Shanghai, 200438, PR China.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.

出版信息

Curr Opin Plant Biol. 2024 Aug;80:102551. doi: 10.1016/j.pbi.2024.102551. Epub 2024 May 21.

DOI:10.1016/j.pbi.2024.102551

PMID:38776573

Abstract

Histone chaperones and histone variants play crucial roles in DNA replication, gene transcription, and DNA repair in eukaryotes. Histone chaperones reversibly promote nucleosome assembly and disassembly by incorporating or evicting histones and histone variants to modulate chromatin accessibility, thereby altering the chromatin states and modulating DNA-related biological processes. Cofactors assist histone chaperones to target specific chromatin regions to regulate the exchange of histones and histone variants. In this review, we summarize recent progress in the interplay between histone variants and chaperones in plants. We discuss the structural basis of chaperone-histone complexes and the mechanisms of their cooperation in regulating gene transcription and plant development.

摘要

组蛋白伴侣和组蛋白变体在真核生物的 DNA 复制、基因转录和 DNA 修复中发挥着关键作用。组蛋白伴侣通过结合或排出组蛋白和组蛋白变体来可逆地促进核小体的组装和拆卸，从而调节染色质的可及性，改变染色质状态，并调节与 DNA 相关的生物学过程。辅助因子帮助组蛋白伴侣靶向特定的染色质区域，以调节组蛋白和组蛋白变体的交换。在这篇综述中，我们总结了植物中组蛋白变体和伴侣之间相互作用的最新进展。我们讨论了伴侣-组蛋白复合物的结构基础及其在调节基因转录和植物发育中的合作机制。