Guo Fangjian, Garvey W Timothy
Department of Obstetrics & Gynecology, and Center for Interdisciplinary Research in Women's Health, The University of Texas Medical Branch, Galveston, TX
Department of Nutrition Sciences, University of Alabama at Birmingham, AL Birmingham Veterans Affairs Medical Center, Birmingham, AL
J Am Heart Assoc. 2016 Jul 13;5(7):e003619. doi: 10.1161/JAHA.116.003619.
No study has quantified trends in the prevalence of cardiovascular disease risk factors and cardiovascular health metrics among obese people in the United States in recent years.
We examined the secular changes in cardiovascular health metrics and key cardiovascular disease risk factors among obese adults (aged ≥20 years) in the United States. We included 18 626 obese adults (body mass index ≥30) from the National Health and Nutrition Examination Survey (NHANES) III and NHANES 1999-2014. Among those obese adults, there were decreases in mean systolic blood pressure, diastolic blood pressure, and total cholesterol levels and increases in mean high-density lipoprotein cholesterol levels and mean hemoglobin A1c levels. Prevalence of blood pressure health and lipid health remained stable during the period 1988-2014, whereas prevalence of blood glucose health decreased significantly during this period. Prevalence of freedom from cardiovascular disease risk factors remained stable at ≈15% among the adult obese population during the period 1988-2014, whereas prevalence of presence of all 3 risk factors increased from 16.4% to 22.4% during this period, commensurate with a decline in those with 1 to 2 risk factors (from 69.6% to 62.4%).
During the past 3 decades, blood pressure health and blood lipid health remained stable or improved, whereas blood glucose health deteriorated among adult obese population. This resulted in an overall decrease in cardiovascular health status among obese adults and greater risk of type 2 diabetes mellitus. The data argue for interventions targeted to those obese persons who are metabolically unhealthy to stem rising rates of diabetes mellitus.
近年来,尚无研究对美国肥胖人群中心血管疾病风险因素的流行趋势及心血管健康指标进行量化分析。
我们研究了美国肥胖成年人(年龄≥20岁)心血管健康指标和主要心血管疾病风险因素的长期变化情况。我们纳入了来自第三次全国健康与营养检查调查(NHANES III)以及1999 - 2014年NHANES的18626名肥胖成年人(体重指数≥30)。在这些肥胖成年人中,平均收缩压、舒张压和总胆固醇水平有所下降,平均高密度脂蛋白胆固醇水平和平均糖化血红蛋白水平有所上升。1988 - 2014年期间,血压健康和血脂健康的患病率保持稳定,而在此期间血糖健康的患病率显著下降。1988 - 2014年期间,成年肥胖人群中无心血管疾病风险因素的患病率稳定在约15%,而同时存在所有3种风险因素的患病率从16.4%升至22.4%,与之相应的是有1至2种风险因素的人群比例下降(从69.6%降至62.4%)。
在过去30年中,成年肥胖人群的血压健康和血脂健康保持稳定或有所改善,而血糖健康状况恶化。这导致肥胖成年人的心血管健康状况总体下降,患2型糖尿病的风险增加。这些数据表明需要针对代谢不健康的肥胖人群采取干预措施,以遏制糖尿病发病率的上升。