Altŭnkova I, Robeva R, Bocheva S, Tsekova D, Neshev Kh
Vutr Boles. 1989;28(1):60-5.
The interest in antilipid A antibodies increases in recent years. By means of an immunoenzyme test developed by the authors the frequency, quantity and characteristic of these antibodies were studied in 46 patients with chronic renal infections and in 36 healthy controls. The frequency of antilipid A antibodies class IgM is 5.7% and of class IgG it is 2.8% in the control group (healthy persons) and it is 41.3% and 19% respectively in the renal patients group. Most frequently their presence and quantity correlate with an active infection or with the convalescent period following antibiotic treatment (62.5%). This allows the use of antilipid A antibodies as a confirming marker for the presence of a heavy Gram negative infection and as a possible index for evaluation the efficacy of the treatment.
近年来，人们对抗脂质A抗体的关注度不断提高。作者通过自行研发的免疫酶试验，对46例慢性肾脏感染患者和36例健康对照者体内这些抗体的频率、数量及特征进行了研究。在对照组（健康人）中，IgM类抗脂质A抗体的频率为5.7%，IgG类为2.8%；而在肾病患者组中，相应的频率分别为41.3%和19%。这些抗体的存在及其数量最常与活动性感染或抗生素治疗后的恢复期相关（62.5%）。这使得抗脂质A抗体可作为严重革兰氏阴性感染存在的确诊标志物，以及评估治疗效果的可能指标。
