Eraky Maysa Ahmad, Abdel-Hady Soha, Abdallah Karim Fetouh
Parasitology Department, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Pediatrics Department, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Korean J Parasitol. 2016 Jun;54(3):335-8. doi: 10.3347/kjp.2016.54.3.335. Epub 2016 Jun 30.
The present study aimed to investigate the possible association of Toxoplasma gondii and Toxocara spp. infections with cryptogenic epilepsy in children. The study was carried out between June 2014 and March 2015. Total 90 children (40 with cryptogenic epilepsy, 30 with non-cryptogenic epilepsy, and 20 healthy control children) were evaluated to determine the anti-Toxocara and anti-T. gondii IgG seropositivity using ELISA kits. Epileptic cases were selected from those attending the pediatrics outpatient clinic of Benha University Hospital, Pediatrics Neurology Unit, and from Benha Specialized Hospital of children. The results showed that the level of anti-T. gondii IgG seropositivity was significantly higher among children with cryptogenic epilepsy (20%) than among children with non-cryptogenic children (0%). In healthy controls (10%), there was no association between toxocariasis seropositivity and cryptogenic epilepsy (only 5.7%; 4 out of 70 cases) among cases and 10% (2 out of 20) among controls. Among toxocariasis IgG positive cases, 3 (7.5%) were cryptogenic, and only 1 (3.3%) was non-cryptogenic. These statistically significant results support the association between T. gondii infection and cryptogenic epilepsy while deny this association with toxocariasis.
本研究旨在调查弓形虫和弓蛔虫属感染与儿童隐源性癫痫之间可能存在的关联。该研究于2014年6月至2015年3月期间进行。共对90名儿童（40名隐源性癫痫患儿、30名非隐源性癫痫患儿和20名健康对照儿童）进行了评估，使用酶联免疫吸附测定试剂盒来确定抗弓蛔虫和抗弓形虫IgG血清阳性率。癫痫病例选自贝纳大学医院儿科门诊、儿科神经科以及贝纳儿童医院。结果显示，隐源性癫痫患儿中抗弓形虫IgG血清阳性率（20%）显著高于非隐源性癫痫患儿（0%）。在健康对照组（10%）中，弓蛔虫病血清阳性与隐源性癫痫之间无关联（病例组中仅5.7%；70例中有4例），对照组中为10%（20例中有2例）。在弓蛔虫病IgG阳性病例中，3例（7.5%）为隐源性，仅1例（3.3%）为非隐源性。这些具有统计学意义的结果支持弓形虫感染与隐源性癫痫之间的关联，而否认与弓蛔虫病存在这种关联。
