Sammons Helen M, Choonara Imti
University of Nottingham, Division of Medical Sciences and Graduate Entry Medicine, Derbyshire Children's Hospital, Derby DE22 3DT, UK.
Children (Basel). 2016 Jan 8;3(1):1. doi: 10.3390/children3010001.
Drug toxicity is, unfortunately, a significant problem in children both in the hospital and in the community. Drug toxicity in children is different to that seen in adults. At least one in 500 children will experience an adverse drug reaction each year. For children in hospital, the risk is far greater (one in ten). Additionally, different and sometimes unique adverse drug reactions are seen in the paediatric age groups. Some of the major cases of drug toxicity historically have occurred in neonates. It is important that we understand the mechanism of action of adverse drug reactions. Greater understanding alongside rational prescribing should hopefully reduce drug toxicity in children in the future.
不幸的是，药物毒性在儿童中是一个严重问题，无论是在医院还是在社区。儿童药物毒性与成人不同。每年至少每500名儿童中就有1人会发生药物不良反应。对于住院儿童来说，风险要大得多（十分之一）。此外，在儿科年龄组中会出现不同的、有时是独特的药物不良反应。历史上一些主要的药物毒性案例发生在新生儿身上。了解药物不良反应的作用机制很重要。随着更深入的了解以及合理用药，有望在未来降低儿童的药物毒性。
