Marton L J, Edwards M S, Levin V A, Lubich W P, Wilson C B
Cancer. 1981 Feb 15;47(4):757-60. doi: 10.1002/1097-0142(19810215)47:4<757::aid-cncr2820470421>3.0.co;2-7.
An earlier study that showed the importance of cerebrospinal fluid polyamine levels for monitoring patients harboring medulloblastomas was expanded to 210 determinations evaluated in 32 patients. The results and conclusions of our earlier study have been confirmed in this expanded patient group. Patient status, with regard to either progression or regression of tumor, was determined by correlating polyamine levels with neurologic examination, computerized tomography, radionuclide scan, cerebrospinal fluid cytology, and myelography. The polyamine assay was predictive of recurrence in 15 patients; three false negatives and no false positives were found. We feel that cerebrospinal fluid polyamine determinations should be a routine diagnostic procedure in the long-term monitoring of patients harboring medulloblastoma.
一项早期研究表明脑脊液多胺水平对于监测成神经管细胞瘤患者具有重要意义，该研究已扩展至对32例患者进行的210次检测。在这个扩大的患者群体中，我们早期研究的结果和结论得到了证实。通过将多胺水平与神经学检查、计算机断层扫描、放射性核素扫描、脑脊液细胞学检查和脊髓造影检查相关联，来确定患者肿瘤进展或消退的状态。多胺检测对15例患者的复发具有预测性；发现3例假阴性，未发现假阳性。我们认为，脑脊液多胺检测应该成为对成神经管细胞瘤患者进行长期监测的常规诊断程序。
