Lessler Justin, Chaisson Lelia H, Kucirka Lauren M, Bi Qifang, Grantz Kyra, Salje Henrik, Carcelen Andrea C, Ott Cassandra T, Sheffield Jeanne S, Ferguson Neil M, Cummings Derek A T, Metcalf C Jessica E, Rodriguez-Barraquer Isabel
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Science. 2016 Aug 12;353(6300):aaf8160. doi: 10.1126/science.aaf8160. Epub 2016 Jul 14.
First discovered in 1947, Zika virus (ZIKV) infection remained a little-known tropical disease until 2015, when its apparent association with a considerable increase in the incidence of microcephaly in Brazil raised alarms worldwide. There is limited information on the key factors that determine the extent of the global threat from ZIKV infection and resulting complications. Here, we review what is known about the epidemiology, natural history, and public health effects of ZIKV infection, the empirical basis for this knowledge, and the critical knowledge gaps that need to be filled.
寨卡病毒（ZIKV）感染于1947年首次被发现，直到2015年，它一直是一种鲜为人知的热带疾病。当时，巴西小头畸形发病率显著上升，且这一现象明显与寨卡病毒感染有关，这在全球范围内拉响了警报。关于决定寨卡病毒感染及其引发并发症对全球威胁程度的关键因素，目前的信息有限。在此，我们回顾了寨卡病毒感染的流行病学、自然史和公共卫生影响，这些认知的实证依据，以及有待填补的关键知识空白。
