Białek Agnieszka, Jelińska Małgorzata, Tokarz Andrzej, Pergół Aleksandra, Pinkiewicz Katarzyna
Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Prostaglandins Other Lipid Mediat. 2016 Nov;126:29-37. doi: 10.1016/j.prostaglandins.2016.07.005. Epub 2016 Jul 11.
Competition with polyunsaturated fatty acids (PUFA) and an impact on eicosanoid biosynthesis may be one of mechanisms of conjugated linolenic acids (CLnA) action. The aim of this study was to investigate the influence of diet supplementation with pomegranate seed oil, containing punicic acid (PA)-one of CLnA isomers, and an aqueous extract of dried bitter melon fruits, administered separately or together, on PUFA and their lipoxygenase metabolites' concentration in serum of rats. Percentage share of fatty acids was diversified in relation to applied supplementation. PA was only detected in serum of pomegranate seed oil supplemented group, where it was about 1%. Cis-9, trans-11 conjugated linoleic acid (rumenic acid, RA) level tended to increase in group supplemented simultaneously with both dietary supplements whereas its highest share in total fatty acids pool was detected in group receiving solely bitter melon dried fruits aqueous extract. This indicates that consumption of bitter melon tea significantly increased RA content in fatty acids pool in serum. However, pomegranate seed oil elevated procarcinogenic 12-hydroxyeicosatetraenoic acid concentration. Taking into account that pomegranate seed oil and bitter melon dried fruits are dietary supplements accessible worldwide and willingly consumed, the biological significance of this phenomenon should be further investigated. We presume, that there may be a need for some precautions concerning the simultaneous use of these products.
与多不饱和脂肪酸（PUFA）竞争以及对类二十烷酸生物合成的影响可能是共轭亚麻酸（CLnA）作用机制之一。本研究的目的是调查单独或一起给予含石榴籽油（石榴酸（PA）——CLnA异构体之一）和苦瓜干果实水提取物的饮食补充剂对大鼠血清中PUFA及其脂氧合酶代谢产物浓度的影响。脂肪酸的百分比份额因所应用的补充剂而异。仅在补充石榴籽油的组血清中检测到PA，其含量约为1%。同时补充两种饮食补充剂的组中，顺式-9，反式-11共轭亚油酸（瘤胃酸，RA）水平有升高趋势，而在仅接受苦瓜干果实水提取物的组中，其在总脂肪酸池中的份额最高。这表明饮用苦瓜茶显著增加了血清脂肪酸池中RA的含量。然而，石榴籽油提高了致癌性12-羟基二十碳四烯酸的浓度。鉴于石榴籽油和苦瓜干果实是全球可获取且人们愿意食用的膳食补充剂，这一现象的生物学意义应进一步研究。我们推测，同时使用这些产品可能需要一些预防措施。
