van Gent Dik C, Kanaar Roland
Department of Molecular Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam 3015, Netherlands.
Department of Molecular Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam 3015, Netherlands Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam 3015, Netherlands
Mol Biol Cell. 2016 Jul 15;27(14):2145-8. doi: 10.1091/mbc.E15-10-0698.
Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.
由于DNA损伤反应缺陷，大多数人类肿瘤会积累大量基因变化。最近，已开发出针对具有特定DNA修复缺陷细胞的小分子抑制剂，为这类肿瘤的精准治疗带来了希望。在此，我们讨论这些疗法背后的基本原理以及如何解决一个重要的瓶颈问题——患者选择。
