Wang Yongyao, Li Linsen, Hou Chen, Lai Ying, Long Jiangang, Liu Jiankang, Zhong Qing, Diao Jiajie
Center for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; State Key Lab of Animal Nutrition, China Agricultural University, Beijing 100193, China.
Semin Cell Dev Biol. 2016 Dec;60:97-104. doi: 10.1016/j.semcdb.2016.07.009. Epub 2016 Jul 12.
Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, membrane fusion is necessary, although different sets of genes and autophagy-related proteins involved in distinct fusion steps have been reported. To clarify the molecular mechanism of membrane fusion in autophagy, to not only expand current knowledge of autophagy, but also benefit human health, this review discusses key findings that elucidate the unique membrane dynamics of autophagy.
自噬是一种保守的自我吞噬过程，用于大量降解细胞质物质，涉及当隔离膜出现时形成的双膜自噬体，以及它们与溶酶体直接融合以进行降解。对于自噬体的早期生物发生及其在溶酶体中的后期降解，膜融合是必要的，尽管已经报道了参与不同融合步骤的不同基因和自噬相关蛋白。为了阐明自噬中膜融合的分子机制，不仅要扩展当前对自噬的认识，还要造福人类健康，本综述讨论了阐明自噬独特膜动力学的关键发现。
