Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany; Laboratory of Biology Bio@SNS, Scuola Normale Superiore, Pisa, Italy.
Trends Genet. 2016 Sep;32(9):523-525. doi: 10.1016/j.tig.2016.06.002. Epub 2016 Jul 13.
Applications of positive selection analysis increase with the number of species for which genome/transcriptome sequences become available. Using the recently sequenced turquoise killifish (Nothobranchius furzeri) genome as an example, we compare two different approaches based on different outgroup selection. The combination of these two methods allows the origin of positively selected sites in aging-related genes of the N. furzeri genome to be determined.
随着基因组/转录组序列可供使用的物种数量的增加，正选择分析的应用也在增加。本文以最近测序的蓝彩鳉（Nothobranchius furzeri）基因组为例，比较了两种基于不同外群选择的不同方法。这两种方法的结合可以确定 N. furzeri 基因组中与衰老相关基因中的正选择位点的起源。
