Eshghi Gholamreza, Khezrian Leila, Alirezaei Pedram
Department of Dermatology, Psoriasis Research Center, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
Acta Med Iran. 2016 Jul;54(7):454-7.
Flushing is a condition with episodic attacks of redness of the skin with a sensation of warmth or burning, this disease causes emotional and functional problems in patients. There is various treatments for this condition; one of them is the use of botulinum toxin-A (BTA). In this prospective pilot study we studied the effect of Botulinum toxin-A (BTA) effect on DLQI of patients with facial flushing, we compared the DLQI before and after treatment. The number of 24 women with facial flushing admitted to the department of dermatology of Hamadan Farshchian Hospital, with the age range of 18 to 60 was enrolled in the study. Patients completed Dermatology Quality of life Index questionnaire before and one month after treatment. In our study 1 unit of BTA was injected intracutaneously per square cm in both sides of cheeks, to a total dose of 30 units per session. All of 24 patients completed the study. The mean age was 37.79±13.13. In all patients, DLQI decreased, and in two months follow up, the mean of DLQI improved from 8.08±1.17 to 4.5±1.21 (P.value<0.005). Based on this study BTA is an effective and safe treatment for facial flushing.
潮红是一种皮肤出现阵发性发红，并伴有温暖或灼烧感的病症，这种疾病会给患者带来情绪和功能方面的问题。针对这种病症有多种治疗方法，其中之一是使用A型肉毒杆菌毒素（BTA）。在这项前瞻性试点研究中，我们研究了A型肉毒杆菌毒素（BTA）对面部潮红患者皮肤病生活质量指数（DLQI）的影响，比较了治疗前后的DLQI。纳入了24名年龄在18至60岁之间、因面部潮红入住哈马丹法尔什奇安医院皮肤科的女性患者进行研究。患者在治疗前和治疗后1个月完成皮肤病生活质量指数问卷。在我们的研究中，每平方厘米在双侧脸颊皮内注射1单位BTA，每次注射总量为30单位。24名患者全部完成了研究。平均年龄为37.79±13.13。所有患者的DLQI均下降，在两个月的随访中，DLQI的平均值从8.08±1.17改善至4.5±1.21（P值<0.005）。基于这项研究，BTA是一种治疗面部潮红有效且安全的方法。
