Naik Piyu Parth
Department of Dermatology, Saudi German Hospital and Clinic, Dubai, United Arab Emirates.
Clin Cosmet Investig Dermatol. 2021 Sep 21;14:1319-1330. doi: 10.2147/CCID.S332247. eCollection 2021.
Botulinum toxin (BoNT) is a neurotoxin produced by the bacterium with a well-known efficacy and safety profile in the focal idiopathic hyperhidrosis treatment. BoNT comprises seven different neurotoxins; however, only toxins A and B are clinically employed. BoNT is lately practiced in off-label therapies for a variety of skin diseases. Scar prevention, hyperhidrosis, rhytides, eccrine nevus, alopecia, psoriasis, Darier disease, bullous skin disease, pompholyx and Raynaud's phenomenon are some of the novel indications for BoNT in cosmetic and notably non-cosmetic aspects of dermatology. To employ BoNT correctly in clinical practice, we must have a thorough understanding of the functional anatomy of the mimetic muscles. An intensive literature search was conducted to update all dermatology-oriented experiments and clinical trials on the described element of BoNT for this general overview of BoNT use in dermatology. This review aims to analyse the role of BoNT in dermatology and cosmetology.
肉毒杆菌毒素（BoNT）是一种由细菌产生的神经毒素，在局限性特发性多汗症治疗中具有众所周知的疗效和安全性。BoNT包含七种不同的神经毒素；然而，临床上仅使用A毒素和B毒素。BoNT最近被用于多种皮肤病的非适应症治疗。预防瘢痕、多汗症、皱纹、小汗腺痣、脱发、银屑病、毛囊角化病、大疱性皮肤病、汗疱疹和雷诺现象是BoNT在皮肤病学美容及尤其是非美容方面的一些新适应症。为了在临床实践中正确使用BoNT，我们必须对表情肌的功能解剖有透彻的了解。进行了深入的文献检索，以更新所有关于BoNT上述内容的面向皮肤科的实验和临床试验，从而对BoNT在皮肤科的应用进行全面概述。本综述旨在分析BoNT在皮肤科和美容学中的作用。
