Department of Vascular and General Surgery, The Hillingdon Hospitals NHS Foundation Trust, Mount Vernon Hospital, Northwood, UK.
Int J Dermatol. 2013 Dec;52(12):1547-50. doi: 10.1111/ijd.12200. Epub 2013 Aug 22.
Idiopathic neck and chest wall flushing could cause disabling effects on patients' quality of life. We aimed to evaluate the effectiveness of botulinum toxin-A (BTA) in the management of idiopathic neck and chest wall flushing. This was a pilot prospective clinical study of patients with severe idiopathic neck and anterior chest wall flushing. Two mouse units of BTA were injected intracutaneously with a maximum dose of 100 units per patient per session. The dermatology life quality index is used as the primary outcome measure. Twenty-two patients were included in the study (18 women, four men) with an average age of 26 years (range 18-48). Twenty patients (90.9%) had immediate improvement with almost complete resolution of their flushing. At four weeks follow-up, 18 of 22 patients were included in the final analysis, significant improvement in quality of life was achieved, and mean baseline dermatology life quality index score 7.78 (SD 3.25) improved significantly to 4.23 (SD 3.44) with a mean difference of 3.56 (SD 4.6; 95%, confidence interval 1.27, 5.84) with paired samples t-test 3.29 (d.f. 17) P < 0.004. BTA may provide an effective treatment in the management of idiopathic neck and chest wall flushing.
特发性颈胸部潮红可能对患者的生活质量造成严重影响。我们旨在评估肉毒毒素 A（BTA）在特发性颈胸部潮红治疗中的效果。这是一项特发性颈胸部潮红患者的前瞻性临床研究。局部皮内注射 2 个单位 BTA，最大剂量为每位患者每次 100 个单位。采用皮肤病生活质量指数作为主要观察指标。本研究共纳入 22 例患者（18 例女性，4 例男性），平均年龄 26 岁（范围 18-48 岁）。20 例（90.9%）患者即时改善，潮红几乎完全消退。4 周随访时，22 例患者中有 18 例纳入最终分析，患者生活质量显著改善，基线皮肤病生活质量指数平均为 7.78（SD 3.25），显著改善至 4.23（SD 3.44），差异均值为 3.56（SD 4.6；95%置信区间 1.27，5.84），配对样本 t 检验为 3.29（自由度 17）P < 0.004。BTA 可能是特发性颈胸部潮红的有效治疗方法。
