Roine R O, Somer H, Kaste M, Viinikka L, Karonen S L
Department of Neurology, University of Helsinki, Finland.
Arch Neurol. 1989 Jul;46(7):753-6. doi: 10.1001/archneur.1989.00520430047015.
The prognostic value of cerebrospinal fluid (CSF) and serum neuron-specific enolase and brain-type creatine kinase isozyme (CK-BB) measurements was studied in 75 consecutive victims of out-of-hospital cardiac arrest. All patients with a CSF neuron-specific enolase level of more than 24 ng/mL 24 hours after cardiac arrest remained unconscious and died. The CSF CK-BB level was as reliable as an index of brain injury. Cerebrospinal fluid neuron-specific enolase, CSF CK-BB and serum neuron-specific enolase levels correlated with the neurological outcome at 3 months. Thus, the analysis of these enzymes in CSF seems to be useful in the early prognostic assessment of cardiac arrest victims.
对75例院外心脏骤停的连续患者进行了脑脊液（CSF）和血清神经元特异性烯醇化酶及脑型肌酸激酶同工酶（CK-BB）检测的预后价值研究。所有心脏骤停后24小时脑脊液神经元特异性烯醇化酶水平超过24 ng/mL的患者均仍处于昏迷状态并死亡。脑脊液CK-BB水平作为脑损伤指标同样可靠。脑脊液神经元特异性烯醇化酶、脑脊液CK-BB和血清神经元特异性烯醇化酶水平与3个月时的神经学转归相关。因此，分析脑脊液中的这些酶似乎有助于对心脏骤停患者进行早期预后评估。
