雷氏雷公藤茎中的三萜类化合物。
Triterpenoids from the stems of Tripterygium regelii.
作者信息
Fan Dongsheng, Parhira Supawadee, Zhu Guo-Yuan, Jiang Zhi-Hong, Bai Li-Ping
机构信息
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Muang, Phitsanulok, Thailand, 65000.
出版信息
Fitoterapia. 2016 Sep;113:69-73. doi: 10.1016/j.fitote.2016.07.006. Epub 2016 Jul 15.
Three new triterpenoids, triregelolides A, B (1, 2), and triregeloic acid (3), were isolated from the stems of Tripterygium regelii along with twenty known triterpene analogues (4-23). The structures of three new compounds were identified by analyzing their NMR spectroscopic and HRESIMS data. Compounds 4, 7, 8, 10, 13, 14, 17, 21-23 were isolated from T. regelii for the first time. Compounds 3, 5, 6, 8, 9, 10, 14 and 16 showed inhibitory effects on the proliferation of human breast cancer cells MCF-7 by 24.1%, 69.6%, 72.8%, 21.6%, 23.1%, 43.3%, 25.5% and 23.5% (p<0.05) at a concentration of 10μM, respectively.
从西南卫矛茎中分离得到三个新的三萜类化合物，即西南卫矛内酯A、B（1, 2）和西南卫矛酸（3），以及二十个已知的三萜类似物（4 - 23）。通过分析它们的核磁共振光谱和高分辨电喷雾电离质谱数据鉴定了这三个新化合物的结构。化合物4、7、8、10、13、14、17、21 - 23首次从西南卫矛中分离得到。化合物3、5、6、8、9、10、14和16在浓度为10μM时，对人乳腺癌细胞MCF - 7的增殖分别显示出24.1%、69.6%、72.8%、21.6%、23.1%、43.3%、25.5%和23.5%的抑制作用（p<0.05）。
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