Fisher C M
Neurology Service, Massachusetts General Hospital, Boston 02114.
Arch Neurol. 1989 Jul;46(7):798-804. doi: 10.1001/archneur.1989.00520430094024.
In an alcoholic patient, catatonia developed while he was receiving disulfiram (Antabuse). Resolution of the question whether his state was classically catatonic required a detailed review of the literature on the subject. The conclusion reached is that the original definition still holds for psychiatric illness, but application of the term to neurological and metabolic states has often been based on imprecise criteria and failure to consider akinetic mutism and extrapyramidal motor disturbances as factors. The action of disulfiram as an inhibitor of dopamine beta hydroxylase provides a possible mechanism for the cerebral toxic effect, but nonetheless the various interpretations remain largely speculative.
在一名酒精中毒患者接受双硫仑（戒酒硫）治疗时出现了紧张症。要确定他的状态是否为典型紧张症，需要详细回顾关于该主题的文献。得出的结论是，原始定义对于精神疾病仍然适用，但将该术语应用于神经和代谢状态时，往往基于不精确的标准，且未将运动不能性缄默症和锥体外系运动障碍视为影响因素。双硫仑作为多巴胺β羟化酶抑制剂的作用为其脑毒性作用提供了一种可能的机制，但尽管如此，各种解释在很大程度上仍属推测。
