Martinez-Guzman M A, Alvarado-Navarro A, Pereira-Suarez A L, Muñoz-Valle J F, Fafutis-Morris M
Doctorado en Ciencias Biomédicas con Orientación en Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, México, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, Jalisco, Mexico; Centro de Investigación en Inmunología y Dermatología/Universidad de Guadalajara, México, Av. Federalismo Norte 3102, Col. Atemajac del Valle, 45190 Zapopan, Jalisco, Mexico.
Centro de Investigación en Inmunología y Dermatología/Universidad de Guadalajara, México, Av. Federalismo Norte 3102, Col. Atemajac del Valle, 45190 Zapopan, Jalisco, Mexico.
Hum Immunol. 2016 Oct;77(10):985-989. doi: 10.1016/j.humimm.2016.07.006. Epub 2016 Jul 15.
Lepromatous Leprosy (LL) is the most common presentation of leprosy in Mexico. LL patients are unable to activate an effective inflammatory response against Mycobacterium leprae probably due to the genetics of the host. Macrophage Migration Inhibitory Factor (MIF) is important to trigger inflammation processes. Two polymorphisms have been reported for human MIF: STR -794 CATT5-8 and SNP -173 G/C. 7-8 CATT repeats at -794 and the C allele at -173 increase the expression of MIF. We aim to determine the association between the polymorphisms in MIF gene and LL. We carried a case and controls study with 100 Mexican LL patients and 100 healthy subjects (HS). PCR was used for genotyping of STR -794 CATT5-8 polymorphism and PCR-RFLP for -173 G/C. We found that LL patients possess high -794 CATT repeats (47.1%) more often than HS (32.7%). In conclusion, a MIF polymorphism is associated with susceptibility to LL in Western Mexican population.
瘤型麻风（LL）是墨西哥最常见的麻风表现形式。LL患者可能由于宿主基因的原因，无法激活针对麻风分枝杆菌的有效炎症反应。巨噬细胞移动抑制因子（MIF）对于触发炎症过程很重要。已报道人类MIF存在两种多态性：STR -794 CATT5-8和SNP -173 G/C。-794处的7-8个CATT重复序列以及-173处的C等位基因会增加MIF的表达。我们旨在确定MIF基因多态性与LL之间的关联。我们对100名墨西哥LL患者和100名健康受试者（HS）进行了病例对照研究。采用PCR对STR -794 CATT5-8多态性进行基因分型，采用PCR-RFLP对-173 G/C进行基因分型。我们发现，LL患者中-794 CATT重复序列高的比例（47.1%）比HS（32.7%）更高。总之，一种MIF多态性与墨西哥西部人群对LL的易感性相关。
