Proust Françoise, Drescher Olivia, Laouan-Sidi Elhadji A, Robinson Elizabeth, Lucas Michel, Dewailly Éric
Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Centre, Québec, QC, Canada.
Public Health Department of the James Bay Cree Territory, Montréal, QC, Canada.
Int J Circumpolar Health. 2016 Jul 15;75:30361. doi: 10.3402/ijch.v75.30361. eCollection 2016.
n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) from fish are known modulators of cardiometabolic risk factors.
To examine fatty acids (FAs) status and the relationship between n-3 LC-PUFA and cardiometabolic risk factors in Cree participants.
We analyzed data from a cross-sectional study (n=829) conducted in Cree adults (aged 18-74 years) from 7 communities of the James Bay territory of Quebec (Canada) in 2005-2009. Sociodemographic, lifestyle, clinical and anthropometric data were collected. FAs were quantified in red blood cells (RBCs) under fasting conditions.
A total of 89% of the participants were overweight (with 69% obesity), 33% had hypertriglyceridemia, 44% had low plasma HDL-c and 77% had fasting plasma insulin ≥90 pmol/l. Total n-3 PUFAs accounted for 6% of total FAs and were higher among older participants, while n-6 PUFAs accounted for 31% of total FAs and were higher among younger participants. According to the adjusted multiple linear regression models, n-3 LC-PUFA was associated (p<0.05) with higher total cholesterol, LDL-c and apo B-100, and was also associated (p<0.05) with lower blood glucose.
Overall, this study showed that n-3 LC-PUFA levels measured in the RBCs of the Cree adults are relatively low and tend towards lower levels among youth. These levels might be insufficient to offset the prevalence of cardiometabolic risk factors.
鱼类中的n-3长链多不饱和脂肪酸（LC-PUFA）是已知的心脏代谢危险因素调节剂。
研究克里族参与者的脂肪酸（FA）状况以及n-3 LC-PUFA与心脏代谢危险因素之间的关系。
我们分析了2005年至2009年在加拿大魁北克省詹姆斯湾地区7个社区对18至74岁克里族成年人进行的一项横断面研究（n = 829）的数据。收集了社会人口统计学、生活方式、临床和人体测量数据。在空腹条件下对红细胞（RBC）中的脂肪酸进行定量。
共有89%的参与者超重（其中69%为肥胖），33%患有高甘油三酯血症，44%血浆高密度脂蛋白胆固醇（HDL-c）水平低，77%空腹血浆胰岛素≥90 pmol/l。总n-3多不饱和脂肪酸占总脂肪酸的6%，在老年参与者中含量较高，而n-6多不饱和脂肪酸占总脂肪酸的31%，在年轻参与者中含量较高。根据调整后的多元线性回归模型，n-3 LC-PUFA与较高的总胆固醇、低密度脂蛋白胆固醇（LDL-c）和载脂蛋白B-100相关（p<0.05），也与较低的血糖相关（p<0.05）。
总体而言，本研究表明，克里族成年人红细胞中测得的n-3 LC-PUFA水平相对较低，且在年轻人中呈下降趋势。这些水平可能不足以抵消心脏代谢危险因素的流行率。
