Labonté M-È, Dewailly E, Lucas M, Couture P, Lamarche B
Institute of Nutrition and Functional Foods, Laval University, Québec, Quebec, Canada.
1] Axe Santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Québec, Quebec, Canada [2] Department of Social and Preventive Medicine, Laval University, Québec, Quebec, Canada.
Eur J Clin Nutr. 2014 Sep;68(9):1042-7. doi: 10.1038/ejcn.2014.125. Epub 2014 Jul 16.
BACKGROUND/OBJECTIVES: We examined the prevalence of elevated plasma high-sensitivity C-reactive protein (hs-CRP) concentrations and associations with red blood cell (RBC) long-chain n-3 polyunsaturated fatty acids (LCn-3PUFA) in the James Bay Cree population from the province of Quebec (Canada).
SUBJECTS/METHODS: A total of 744 Cree adults (18-91 years) from seven communities of Eastern James Bay were included in these cross-sectional analyses. Associations between RBC LCn-3PUFA and proinflammatory markers (hs-CRP, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)) were assessed by using multivariate general linear models with adjustment for sex, age and waist circumference. An arbitrary inflammation score was defined based on the sum of the quartiles of hs-CRP, IL-6 and TNF-α concentrations (range=3-12).
Elevated hs-CRP concentrations (>3 mg/l) were present in 46.9% (95% confidence interval (CI) 43.3-50.5) of the James Bay Cree population. RBC docosapentaenoic acid (DPAn-3; C22:5n-3) was inversely associated with hs-CRP, TNF-α and the inflammation score (all P trend<0.02), whereas eicosapentaenoic acid (C20:5n-3) and docosahexaenoic acid (C22:6n-3) in RBC were not associated with inflammation (all P trend>0.18). Among participants with RBC DPAn-3 levels above the median of the population, odds ratio of having an elevated inflammation score (≥9) was 0.67 (95% CI, 0.48-0.93) compared with participants below the median.
RESULTS indicate that low-grade systemic inflammation is highly prevalent and that higher RBC DPAn-3 levels are associated with a lower risk of systemic inflammation in the James Bay Cree population.
背景/目的：我们研究了加拿大魁北克省詹姆斯湾克里人群中血浆高敏C反应蛋白（hs-CRP）浓度升高的患病率及其与红细胞（RBC）长链n-3多不饱和脂肪酸（LCn-3PUFA）的关系。
对象/方法：来自东詹姆斯湾七个社区的744名克里成年人（18 - 91岁）纳入了这些横断面分析。通过使用多变量一般线性模型，并对性别、年龄和腰围进行调整，评估RBC LCn-3PUFA与促炎标志物（hs-CRP、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α））之间的关联。基于hs-CRP、IL-6和TNF-α浓度的四分位数总和定义了一个任意炎症评分（范围 = 3 - 12）。
詹姆斯湾克里人群中46.9%（95%置信区间（CI）43.3 - 50.5）的人hs-CRP浓度升高（>3 mg/l）。红细胞二十二碳五烯酸（DPAn-3；C22:5n-3）与hs-CRP、TNF-α和炎症评分呈负相关（所有P趋势<0.02），而红细胞中的二十碳五烯酸（C20:5n-3）和二十二碳六烯酸（C22:6n-3）与炎症无关（所有P趋势>0.18）。在红细胞DPAn-3水平高于人群中位数的参与者中，炎症评分≥9的参与者的比值比为0.67（95% CI，0.48 - 0.93），而低于中位数的参与者为对照。
结果表明，低度全身炎症在詹姆斯湾克里人群中非常普遍，较高的红细胞DPAn-3水平与较低的全身炎症风险相关。
