Hellmund Chris, Lever Andrew M L
Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Viruses. 2016 Jul 14;8(7):192. doi: 10.3390/v8070192.
The tremendous progress made in unraveling the complexities of human immunodeficiency virus (HIV) replication has resulted in a library of drugs to target key aspects of the replication cycle of the virus. Yet, despite this accumulated wealth of knowledge, we still have much to learn about certain viral processes. One of these is virus assembly, where the viral genome and proteins come together to form infectious progeny. Here we review this topic from the perspective of how the route to production of an infectious virion is orchestrated by the viral genome, and we compare and contrast aspects of the assembly mechanisms employed by HIV-1 with those of other RNA viruses.
在揭示人类免疫缺陷病毒（HIV）复制复杂性方面取得的巨大进展，催生了一系列针对该病毒复制周期关键环节的药物。然而，尽管积累了如此丰富的知识，我们对某些病毒过程仍有许多需要了解的地方。其中之一就是病毒组装，即病毒基因组和蛋白质聚集在一起形成有感染性的子代病毒。在此，我们从病毒基因组如何精心安排产生有感染性子代病毒的途径这一角度来审视这一主题，并对HIV-1与其他RNA病毒所采用的组装机制的各个方面进行比较和对比。
