Ehlerding Emily B, Chen Feng, Cai Weibo
Department of Medical Physics University of Wisconsin Madison, WI 53706, USA.
Department of Radiology University of Wisconsin Madison, WI 53706, USA.
Adv Sci (Weinh). 2016 Feb;3(2). doi: 10.1002/advs.201500223. Epub 2015 Oct 27.
Personalized treatment plans for cancer therapy have been at the forefront of oncology research for many years. With the advent of many novel nanoplatforms, this goal is closer to realization today than ever before. Inorganic nanoparticles hold immense potential in the field of nano-oncology, but have considerable toxicity concerns that have limited their translation to date. In this review, an overview of emerging biologically safe inorganic nanoplatforms is provided, along with considerations of the challenges that need to be overcome for cancer theranostics with inorganic nanoparticles to become a reality. The clinical and preclinical studies of both biodegradable and renal clearable inorganic nanoparticles are discussed, along with their implications.
多年来，癌症治疗的个性化治疗方案一直处于肿瘤学研究的前沿。随着许多新型纳米平台的出现，如今这一目标比以往任何时候都更接近实现。无机纳米粒子在纳米肿瘤学领域具有巨大潜力，但存在相当大的毒性问题，这限制了它们至今的临床转化。在这篇综述中，我们概述了新兴的生物安全无机纳米平台，并考虑了无机纳米粒子用于癌症诊疗要成为现实需要克服的挑战。我们还讨论了可生物降解和可经肾脏清除的无机纳米粒子的临床和临床前研究及其意义。
