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硫酸软骨素衍生的治疗性纳米粒子用于靶向药物递送。

Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery.

机构信息

Department of Chemistry, Ångström Laboratory, Uppsala University, SE-75121, Sweden.

Department of Bioscience and Nutrition, Karolinska Institute, Huddinge, Stockholm, SE-14183, Sweden.

出版信息

Biomater Sci. 2016 Aug 16;4(9):1310-3. doi: 10.1039/c6bm00335d.

Abstract

Glycosaminoglycan derived nanoparticles are a promising delivery system owing to their unique tumour targeting ability. Exploiting fluorescein for inducing amphiphilicity in these biopolymers provides inherent imaging and drug stabilization capabilities by π-π stacking interactions with aromatic antineoplastic agents. This offers a versatile and highly customizable nanocarrier with narrow size distribution and high drug loading efficiency (80%) with sustained drug release.

摘要

糖胺聚糖衍生纳米颗粒是一种很有前途的递药系统,因为它们具有独特的肿瘤靶向能力。利用荧光素在这些生物聚合物中诱导两亲性,通过与芳香族抗癌药物的π-π 堆积相互作用,提供了内在的成像和药物稳定能力。这提供了一种具有窄粒径分布和高载药效率(80%)的多功能且高度可定制的纳米载体,具有持续的药物释放。

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