State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Oxid Med Cell Longev. 2019 Aug 14;2019:5738368. doi: 10.1155/2019/5738368. eCollection 2019.
Diabetic foot ulcers (DFUs), the most serious complication of diabetes mellitus, can induce high morbidity, the need to amputate lower extremities, and even death. Although many adjunctive strategies have been applied for the treatment of DFUs, the low treatment efficiency, potential side effects, and high cost are still huge challenges. Recently, nanomaterial-based drug delivery systems (NDDSs) have achieved targeted drug delivery and controlled drug release, offering great promises in various therapeutics for diverse disorders. Additionally, the radial extracorporeal shock wave (rESW) has been shown to function as a robust trigger source for the NDDS to release its contents, as the rESW harbors a potent capability in generating pressure waves and in creating the cavitation effect. Here, we explored the performance of oxygen-loaded nanoperfluorocarbon (Nano-PFC) combined with the rESW as a treatment for DFUs. Prior to assessment, we first demonstrated the high oxygen affinity and great biocompatibility of Nano-PFC. Moreover, the rESW-responsive oxygen release behavior from oxygen-saturated Nano-PFC was also successfully verified and . Importantly, the wound healing of DFUs was significantly accelerated due to improved blood microcirculation, which was a result of rESW therapy (rESWT), and the targeted release of oxygen into the wound from oxygen-loaded Nano-PFC, which was triggered by the rESW. Collectively, the oxygen-saturated Nano-PFC and rESW provide a completely new approach to treat DFUs, and this study highlights the advantages of combining nanotechnology with rESW in therapeutics.
糖尿病足溃疡（DFUs）是糖尿病最严重的并发症之一，可导致高发病率、下肢截肢甚至死亡。尽管已经应用了许多辅助治疗策略，但治疗效率低、潜在副作用和高成本仍然是巨大的挑战。最近，基于纳米材料的药物传递系统（NDDSs）已实现了靶向药物传递和控制药物释放，为各种疾病的治疗提供了很大的希望。此外，径向体外冲击波（rESW）已被证明是 NDDS 释放其内容的强大触发源，因为 rESW 具有产生压力波和产生空化效应的强大能力。在这里，我们研究了载氧纳米全氟碳化物（Nano-PFC）与 rESW 联合治疗 DFUs 的性能。在评估之前，我们首先证明了 Nano-PFC 具有高氧亲和力和良好的生物相容性。此外，还成功验证和证实了氧饱和 Nano-PFC 从 rESW 响应性释放氧气的行为。重要的是，由于 rESWT 改善了血液微循环，以及 rESW 触发的载氧 Nano-PFC 向伤口的靶向释放氧气，DFUs 的伤口愈合得到了显著加速。总之，氧饱和的 Nano-PFC 和 rESW 为治疗 DFUs 提供了一种全新的方法，本研究强调了将纳米技术与 rESW 结合用于治疗的优势。
