癌症相关血栓性微血管病
Cancer-associated thrombotic microangiopathy.
作者信息
Govind Babu K, Bhat Gita R
机构信息
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr MH Marigowda road, Hombegowdanagar, Bangalore-560029, India.
出版信息
Ecancermedicalscience. 2016 Jun 28;10:649. doi: 10.3332/ecancer.2016.649. eCollection 2016.
Abstract
Cancer-associated thrombotic microangiopathy refers to a group of disorders characterised by microvascular thrombosis, thrombocytopenia, and ischaemic end-organ damage. Haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura are the two major subtypes. It can be a manifestation of the malignancy itself or a complication of its therapy. The addition of several new drugs to the therapeutic armamentarium of cancer has brought to light several novel causative factors of this hitherto uncommon complication. This review covers the aetiology, pathogenesis, clinical manifestations, complications, and the management of cancer-associated thrombotic microangiopathy. Careful review of the patient's medical records coupled with the correlation of clinical findings and laboratory reports can help clinch the diagnosis and institute appropriate treatment on time.
摘要
癌症相关血栓性微血管病是指一组以微血管血栓形成、血小板减少和缺血性终末器官损伤为特征的疾病。溶血尿毒综合征和血栓性血小板减少性紫癜是两种主要亚型。它可以是恶性肿瘤本身的一种表现，也可以是其治疗的并发症。癌症治疗手段中新增的几种药物揭示了这种迄今为止不常见并发症的几种新致病因素。本综述涵盖了癌症相关血栓性微血管病的病因、发病机制、临床表现、并发症及管理。仔细查阅患者病历，并将临床发现与实验室报告相关联，有助于确诊并及时进行适当治疗。
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