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靶源性trkB受体对运动神经元突触联系维持的选择性需求。

Selective Requirement for Maintenance of Synaptic Contacts onto Motoneurons by Target-Derived trkB Receptors.

作者信息

Zhu Xiya, Ward Patricia J, English Arthur W

机构信息

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Neural Plast. 2016;2016:2371893. doi: 10.1155/2016/2371893. Epub 2016 Jun 28.

DOI:10.1155/2016/2371893
PMID:27433358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4940568/
Abstract

Synaptic contacts onto motoneurons were studied in mice in which the gene for the trkB neurotrophin receptor was knocked out selectively in a subset of spinal motoneurons. The extent of contacts by structures immunoreactive for either of two different vesicular glutamate transporters (VGLUT1 and VGLUT2), the vesicular GABA transporter, or glutamic acid decarboxylase 67 (GAD67) with the somata of motoneurons, was studied in wild type and trkB knockout cells in tamoxifen treated male and female SLICK-trkB(-/-) mice. Selective knockout of the trkB gene resulted in a marked reduction in contacts made by VGLUT2- and GAD67-immunoreactive structures in both sexes and a significant reduction in contacts containing only glycine in male mice. No reduction was found for glycinergic contacts in female mice or for VGLUT1 immunoreactive contacts in either sex. Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons.

摘要

在小鼠中研究了与运动神经元的突触联系，这些小鼠的脊髓运动神经元亚群中trkB神经营养因子受体基因被选择性敲除。在他莫昔芬处理的雄性和雌性SLICK-trkB(-/-)小鼠的野生型和trkB基因敲除细胞中，研究了对两种不同的囊泡谷氨酸转运体（VGLUT1和VGLUT2）、囊泡GABA转运体或谷氨酸脱羧酶67（GAD67）呈免疫反应的结构与运动神经元胞体的接触程度。trkB基因的选择性敲除导致两性中VGLUT2和GAD67免疫反应性结构的接触显著减少，以及雄性小鼠中仅含甘氨酸的接触显著减少。在雌性小鼠中未发现甘氨酸能接触减少，在两性中VGLUT1免疫反应性接触也未减少。通过突触后trkB受体的信号传导被认为是维持运动神经元上部分（而非全部）突触联系的细胞机制的重要组成部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/6225358b6586/NP2016-2371893.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/2470c808f9f0/NP2016-2371893.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/6431a75bccab/NP2016-2371893.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/0de91b1a0aff/NP2016-2371893.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/6225358b6586/NP2016-2371893.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/2470c808f9f0/NP2016-2371893.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/6431a75bccab/NP2016-2371893.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/0de91b1a0aff/NP2016-2371893.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5e/4940568/6225358b6586/NP2016-2371893.004.jpg

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