Müsri Fatma Yalçin, Mutlu Hasan, Karaağaç Mustafa, Eryilmaz Melek Karakurt, Gündüz Şeyda, Artaç Mehmet
Department of Medical Oncology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Department of Medical Oncology, Faculty of Medicine, Meram University, Konya, Turkey.
J Gastric Cancer. 2016 Jun;16(2):78-84. doi: 10.5230/jgc.2016.16.2.78. Epub 2016 Jun 24.
The aim of this study was to determine whether surgical resection of the primary tumor contributes to survival in patients with metastatic gastric cancer.
A total of 288 patients with metastatic gastric cancer from the Akdeniz University, Antalya Training and Research Hospital, and the Meram University of Konya database were retrospectively analyzed. The effect of primary tumor resection on survival of patients with metastatic gastric cancer was investigated using the log-rank test. Kaplan-Meier survival estimates were calculated. Multivariate analysis was performed using Cox proportional hazards regression modeling.
The median overall survival was 12.0 months (95% confidence intewrval [CI], 10.413.6 months) and 7.8 months (95% CI, 5.510.0 months) for patients with and without primary tumor resection, respectively (P<0.001). The median progression-free survival was 8.3 months (95% CI, 7.19.5 months) and 6.2 months (95% CI, 5.86.7 months) for patients with and without primary tumor resection, respectively (P=0.002).
Non-curative gastrectomy in patients with metastatic gastric cancer might increase their survival rate regardless of the occurrence of life-threatening tumor-related complications.
本研究旨在确定原发性肿瘤的手术切除是否有助于转移性胃癌患者的生存。
回顾性分析了来自阿克德尼兹大学、安塔利亚培训与研究医院以及科尼亚梅拉姆大学数据库的288例转移性胃癌患者。使用对数秩检验研究原发性肿瘤切除对转移性胃癌患者生存的影响。计算了Kaplan-Meier生存估计值。使用Cox比例风险回归模型进行多变量分析。
原发性肿瘤切除患者和未切除患者的中位总生存期分别为12.0个月（95%置信区间[CI]，10.413.6个月）和7.8个月（95%CI，5.510.0个月）（P<0.001）。原发性肿瘤切除患者和未切除患者的中位无进展生存期分别为8.3个月（95%CI，7.19.5个月）和6.2个月（95%CI，5.86.7个月）（P=0.002）。
转移性胃癌患者的非根治性胃切除术可能会提高其生存率，无论是否发生危及生命的肿瘤相关并发症。
