Ghaffaripour Sina, Mahmoudi Hilda, Eghbal Hossein, Rahimi Ashkan
Shiraz Anesthesiology and Critical Care research center, Department of anesthesiology, Shiraz University of Medical Sciences.
GME, Aventura Hospital and Medical Center.
Cureus. 2016 Jun 1;8(6):e626. doi: 10.7759/cureus.626.
Post-operative pain control is an important concern for both patients and physicians. Magnesium is being used as an adjuvant for anesthesia and analgesia during and after various surgeries. We aimed to investigate the effects of intravenous magnesium sulfate on post-operative analgesia after laminectomy. Methods Materials: In this randomized double-blind controlled clinical trial, we enrolled 40 adult patients aged 18-60 with American Society of Anesthesiologists (ASA) Class I-II who were candidates for elective laminectomy. The patients were randomly assigned in two control groups and were similarly anesthetized. In the case group, after the induction of anesthesia, a loading dose of magnesium sulfate (30 mg/kg) was administered within five to 10 minutes followed by a maintenance dose of 10 mg/kg/hr up to the end of the surgery; while, the patients in the control group received the same volume of saline. After the surgery, all patients received a patient-controlled intravenous analgesia (PCA) pump containing morphine. The first time of using PCA, the amount of consumed morphine during the first 24 hours, and pain score were recorded at 6,12,18 and 24 hours in the post-operative period.
There was no significant difference between the two groups with respect to the amount of morphine consumed in 24 hours after the surgery (P value =0.23), the first time of using of PCA pump (P value =0.79) and pain intensity (P value=0.52).
The infusion of Magnesium Sulfate during laminectomy had no effect on patients' pain and opioid requirement during the first 24 hours after the surgery.
术后疼痛控制是患者和医生共同关注的重要问题。镁正被用作各种手术期间及术后麻醉和镇痛的辅助药物。我们旨在研究静脉注射硫酸镁对椎板切除术后镇痛的影响。
在这项随机双盲对照临床试验中，我们纳入了40名年龄在18 - 60岁、美国麻醉医师协会（ASA）分级为I - II级、拟行择期椎板切除术的成年患者。患者被随机分为两个对照组，并接受相似的麻醉。在病例组中，麻醉诱导后，在5至10分钟内给予负荷剂量的硫酸镁（30mg/kg），随后以10mg/kg/小时的维持剂量持续至手术结束；而对照组患者接受相同体积的生理盐水。术后，所有患者均接受含吗啡的患者自控静脉镇痛（PCA）泵。记录术后6、12、18和24小时使用PCA的首次时间、前24小时吗啡消耗量以及疼痛评分。
两组患者术后24小时吗啡消耗量（P值 = 0.23）、使用PCA泵的首次时间（P值 = 0.79）和疼痛强度（P值 = 0.52）之间无显著差异。
椎板切除术中输注硫酸镁对患者术后24小时内的疼痛和阿片类药物需求量无影响。
