Montazeri Kamran, Soltani Hasanali, Varposhti Mojtaba Rahimi, Mohajeri Leila
Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Anesthesiology, Medical School of Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2018 Feb 28;7:39. doi: 10.4103/abr.abr_48_15. eCollection 2018.
The present study has been designed to compare the effect of magnesium sulfate with mannitol on reducing intraocular pressure (IOP).
During the phacoemulsification surgery, 105 patients randomly divided into three groups receiving 20% mannitol at a dose of 0.3 g/kg, 50% magnesium sulfate at a dose of 20 mg/kg, and placebo (normal saline), with the same volume (100 ml) and infusion time (10 min), were used for the first, second, and third groups, respectively. The IOP was measured before and immediately after the injection and 5 min after the end of the surgery and compared between the groups.
The mean IOP immediately after the injection had a significant difference in three groups (mannitol: 15.2 ± 2.5, magnesium sulfate: 14.7 ± 1.9, and normal saline: 13.8 ± 2.8; = 0.044), and the IOP had a significant difference between normal saline and mannitol groups (0.027) while there was no significant difference between mannitol and magnesium sulfate groups ( = 0.34) and also between magnesium sulfate and normal saline groups ( = 0.2).
Using magnesium sulfate had no effect on changes in the IOP and hemodynamic of patients during the surgery. Using mannitol may be effective in reducing IOP while no effect of magnesium sulfate on IOP was found.
本研究旨在比较硫酸镁与甘露醇降低眼压（IOP）的效果。
在白内障超声乳化手术期间，105例患者被随机分为三组，分别接受剂量为0.3 g/kg的20%甘露醇、剂量为20 mg/kg的50%硫酸镁和安慰剂（生理盐水），三者体积相同（100 ml）且输注时间相同（10分钟），第一组、第二组和第三组分别使用上述药物。在注射前、注射后即刻以及手术结束后5分钟测量眼压，并在组间进行比较。
注射后即刻三组的平均眼压存在显著差异（甘露醇组：15.2±2.5，硫酸镁组：14.7±1.9，生理盐水组：13.8±2.8；P = 0.044），生理盐水组与甘露醇组之间的眼压存在显著差异（P = 0.027），而甘露醇组与硫酸镁组之间（P = 0.34）以及硫酸镁组与生理盐水组之间（P = 0.2）均无显著差异。
手术期间使用硫酸镁对患者眼压和血流动力学变化无影响。使用甘露醇可能有效降低眼压，而未发现硫酸镁对眼压有影响。
