Kottanattu Lisa, Lava Sebastiano A G, Helbling Rossana, Simonetti Giacomo D, Bianchetti Mario G, Milani Gregorio P
Pediatric Department of Southern Switzerland, Bellinzona, Switzerland.
Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; University Children's Hospital, Inselspital, and University of Bern, Bern, Switzerland.
J Clin Virol. 2016 Sep;82:51-55. doi: 10.1016/j.jcv.2016.06.017. Epub 2016 Jul 1.
Acute pancreatitis and acalculous cholecystitis have been occasionally reported in primary acute symptomatic Epstein-Barr virus infection. We completed a review of the literature and retained 48 scientific reports published between 1966 and 2016 for the final analysis. Acute pancreatitis was recognized in 14 and acalculous cholecystitis in 37 patients with primary acute symptomatic Epstein-Barr virus infection. In all patients, the features of acute pancreatitis or acalculous cholecystitis concurrently developed with those of primary acute symptomatic Epstein-Barr virus infection. Acute pancreatitis and acalculous cholecystitis resolved following a hospital stay of 25days or less. Acalculous cholecystitis was associated with Gilbert-Meulengracht syndrome in two cases. In conclusion, this thorough analysis indicates that acute pancreatitis and acalculous cholecystitis are unusual but plausible complications of primary acute symptomatic Epstein-Barr virus infection. Pancreatitis and cholecystitis deserve consideration in cases with severe abdominal pain. These complications are usually rather mild and resolve spontaneously without sequelae.
原发性急性症状性爱泼斯坦-巴尔病毒感染偶有并发急性胰腺炎和无结石性胆囊炎的报道。我们对文献进行了回顾，并筛选出1966年至2016年间发表的48篇科学报告进行最终分析。在原发性急性症状性爱泼斯坦-巴尔病毒感染患者中，14例被诊断为急性胰腺炎，37例被诊断为无结石性胆囊炎。所有患者中，急性胰腺炎或无结石性胆囊炎的症状均与原发性急性症状性爱泼斯坦-巴尔病毒感染的症状同时出现。急性胰腺炎和无结石性胆囊炎在住院25天或更短时间后痊愈。两例无结石性胆囊炎与吉尔伯特-默伦格拉赫特综合征相关。总之，这项全面分析表明，急性胰腺炎和无结石性胆囊炎是原发性急性症状性爱泼斯坦-巴尔病毒感染不常见但可能出现的并发症。对于有严重腹痛的病例，应考虑胰腺炎和胆囊炎。这些并发症通常较为轻微，可自发痊愈且无后遗症。
