基因组重编程的几何控制与建模
Geometric control and modeling of genome reprogramming.
作者信息
Uhler Caroline, Shivashankar G V
机构信息
a Department of Electrical Engineering & Computer Science , and Institute for Data, Systems and Society, MIT , Cambridge , MA , USA.
b Mechanobiology Institute National University of Singapore , Singapore.
出版信息
Bioarchitecture. 2016 Jul 3;6(4):76-84. doi: 10.1080/19490992.2016.1201620. Epub 2016 Jul 19.
Abstract
Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming.
摘要
细胞几何学与组织微环境中的基因表达模式紧密相关。这一观点综合了相关证据，即染色体的三维组织是基因组程序几何控制的关键中间环节。我们通过实验和建模相结合的方式，概述了解码控制细胞稳态和重编程的机械基因组密码的方法。
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