Kitayama Shinobu, Akutsu Satoshi, Uchida Yukiko, Cole Steve W
University of Michigan, Ann Arbor, MI 48109, USA.
Hitotsubashi University, Tokyo 101-8439, Japan.
Psychoneuroendocrinology. 2016 Oct;72:175-81. doi: 10.1016/j.psyneuen.2016.07.004. Epub 2016 Jul 12.
The meaning in life, typically reflected in a sense of purpose, growth, or social embeddedness (called eudaimonic well-being, EWB), has been linked to favorable health outcomes. In particular, this experience is inversely associated with the conserved transcriptional response to adversity (CTRA), which involves up-regulation of genes linked to inflammation and down-regulation of genes linked to viral resistance. So far, however, little is known about how this transcriptome profile might be situated in specific socio-cultural contexts. Here, we tested 106 male workers at a large Japanese IT firm and found that the CTRA is inversely associated not only with general EWB but also with a more contextualized sense of meaning derived from the perceived significance of one's work and a sense of interdependence with others in the workplace. These results expand previous links between personal well-being and CTRA gene expression to include the socio-cultural determinants of meaning in life.
生活意义通常体现在目标感、成长或社会融入感中（称为心理幸福感，EWB），它与良好的健康结果相关联。特别是，这种体验与保守的逆境转录反应（CTRA）呈负相关，CTRA涉及与炎症相关基因的上调和与病毒抗性相关基因的下调。然而，到目前为止，对于这种转录组谱如何在特定的社会文化背景中定位，人们知之甚少。在这里，我们对一家大型日本信息技术公司的106名男性员工进行了测试，发现CTRA不仅与一般的EWB呈负相关，而且与源自工作感知重要性的更具情境化的意义感以及工作场所中与他人的相互依存感呈负相关。这些结果扩展了个人幸福感与CTRA基因表达之间的先前联系，将生活意义的社会文化决定因素也包括在内。
