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中药材的钙拮抗剂活性筛选：从广藿香地上部分和乌梅果实中鉴定活性成分。

The screening of Chinese crude drugs for Ca2+ antagonist activity: identification of active principles from the aerial part of Pogostemon cablin and the fruits of Prunus mume.

作者信息

Ichikawa K, Kinoshita T, Sankawa U

出版信息

Chem Pharm Bull (Tokyo). 1989 Feb;37(2):345-8. doi: 10.1248/cpb.37.345.

DOI:10.1248/cpb.37.345
PMID:2743480
Abstract

Hot aqueous extracts of 134 Chinese crude drugs were subjected to screening for inhibitory activity on K+ contracture of guinea pig taenia coli, and significant activity was observed in 17 crude drugs. Chemical investigations of two crude drugs, Kakko and Ubai, which originate from Pogostemon cablin and Prunus mume, respectively, were undertaken, and patchouli alcohol (I) and 5-(hydroxymethyl)-2-furaldehyde (II) were identified as their active principles, respectively.

摘要

对134种中药的热水提取物进行了抑制豚鼠结肠带K⁺收缩活性的筛选，在17种中药中观察到显著活性。分别对源自广藿香和梅的两种中药藿香和乌梅进行了化学研究，分别鉴定出广藿香醇（I）和5-（羟甲基）-2-糠醛（II）为其活性成分。

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