Touitou Y, Touitou C, Bogdan A, Reinberg A, Motohashi Y, Auzéby A, Beck H
Department of Biochemistry, Faculté de Médecine Pitié, Salpêtrière, Paris.
Clin Chim Acta. 1989 Apr 14;180(3):245-54. doi: 10.1016/0009-8981(89)90006-5.
The circadian and seasonal variations of a set of routinely determined variables (chloride, sodium, potassium, calcium, inorganic phosphorus, magnesium, creatinine, urea and urate) were documented in young men (mean age +/- SD: 24.0 +/- 3.9 yr) and in healthy elderly men (75.3 +/- 6.6) and women (78.2 +/- 9.1). The same urinary variables, except magnesium, were studied in young men. The circadian variability of serum variables was between 2 and 11% except for serum inorganic phosphorus (12-22% according to the group). By contrast, urinary chloride, sodium and potassium revealed large peak-trough differences (55-75%) and the variability of urinary creatinine, urate and urea was also not negligible (20-30%). ANOVA validated seasonal variations for most of the plasma variables and for urinary calcium, phosphorus and uric acid. No age or sex difference in either 24 h means or amplitudes could be observed. These data are of interest for the concept of reference values, for the diagnosis of certain bone and renal disease as well as for chronooptimization in treatment of potential electrolytes deficiency states.
在年轻男性（平均年龄±标准差：24.0±3.9岁）、健康老年男性（75.3±6.6岁）和健康老年女性（78.2±9.1岁）中记录了一组常规测定变量（氯离子、钠离子、钾离子、钙离子、无机磷、镁离子、肌酐、尿素和尿酸盐）的昼夜和季节变化情况。除镁离子外，对年轻男性的相同尿液变量也进行了研究。血清变量的昼夜变异性在2%至11%之间，但血清无机磷除外（根据组别为12% - 22%）。相比之下，尿氯离子、钠离子和钾离子显示出较大的峰谷差异（55% - 75%），尿肌酐、尿酸盐和尿素的变异性也不可忽视（20% - 30%）。方差分析验证了大多数血浆变量以及尿钙、磷和尿酸的季节变化。在24小时均值或波动幅度方面未观察到年龄或性别差异。这些数据对于参考值概念、某些骨骼和肾脏疾病的诊断以及潜在电解质缺乏状态治疗中的时间优化具有重要意义。
