Vanniyasingam Thuva, Cunningham Charles E, Foster Gary, Thabane Lehana
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
BMJ Open. 2016 Jul 19;6(7):e011985. doi: 10.1136/bmjopen-2016-011985.
Discrete choice experiments (DCEs) are routinely used to elicit patient preferences to improve health outcomes and healthcare services. While many fractional factorial designs can be created, some are more statistically optimal than others. The objective of this simulation study was to investigate how varying the number of (1) attributes, (2) levels within attributes, (3) alternatives and (4) choice tasks per survey will improve or compromise the statistical efficiency of an experimental design.
A total of 3204 DCE designs were created to assess how relative design efficiency (d-efficiency) is influenced by varying the number of choice tasks (2-20), alternatives (2-5), attributes (2-20) and attribute levels (2-5) of a design. Choice tasks were created by randomly allocating attribute and attribute level combinations into alternatives.
Relative d-efficiency was used to measure the optimality of each DCE design.
DCE design complexity influenced statistical efficiency. Across all designs, relative d-efficiency decreased as the number of attributes and attribute levels increased. It increased for designs with more alternatives. Lastly, relative d-efficiency converges as the number of choice tasks increases, where convergence may not be at 100% statistical optimality.
Achieving 100% d-efficiency is heavily dependent on the number of attributes, attribute levels, choice tasks and alternatives. Further exploration of overlaps and block sizes are needed. This study's results are widely applicable for researchers interested in creating optimal DCE designs to elicit individual preferences on health services, programmes, policies and products.
离散选择实验(DCEs)通常用于引出患者偏好,以改善健康结果和医疗服务。虽然可以创建许多部分因子设计,但有些在统计上比其他设计更优。本模拟研究的目的是调查改变(1)属性数量、(2)属性内的水平数量、(3)备选方案数量以及(4)每次调查的选择任务数量如何提高或损害实验设计的统计效率。
总共创建了3204个DCE设计,以评估设计的选择任务数量(2 - 20)、备选方案数量(2 - 5)、属性数量(2 - 20)和属性水平数量(2 - 5)的变化如何影响相对设计效率(d - 效率)。通过将属性和属性水平组合随机分配到备选方案中来创建选择任务。
使用相对d - 效率来衡量每个DCE设计的最优性。
DCE设计复杂性影响统计效率。在所有设计中,相对d - 效率随着属性和属性水平数量的增加而降低。对于具有更多备选方案的设计,它会增加。最后,相对d - 效率随着选择任务数量的增加而收敛,收敛可能并非达到100%的统计最优性。
实现100%的d - 效率在很大程度上取决于属性数量、属性水平数量、选择任务数量和备选方案数量。需要进一步探索重叠和区组大小。本研究结果广泛适用于有兴趣创建最优DCE设计以引出个体对健康服务、项目、政策和产品偏好的研究人员。