Photobiology Unit, Dermatology Centre, The University of Manchester & Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M6 8HD, UK.
Molecules. 2020 Nov 18;25(22):5398. doi: 10.3390/molecules25225398.
Photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). BCC is the most common human cancer and also a convenient cancer in which to study PDT treatment. This review clarifies challenges to researchers evident from the clinical use of PDT in BCC treatment. It outlines the context of PDT and how PDT treatments for BCC have been developed hitherto. The sections examine the development of systemic and subsequently topical photosensitizers, light delivery regimens, and the use of PDT in different patient populations and subtypes of BCC. The outcomes of topical PDT are discussed in comparison with alternative treatments, and topical PDT applications in combination and adjuvant therapy are considered. The intention is to summarize the clinical relevance and expose areas of research need in the BCC context, ultimately to facilitate improvements in PDT treatment.
光动力疗法（PDT）是治疗低危基底细胞癌（BCC）的一种成熟治疗选择。BCC 是最常见的人类癌症，也是研究 PDT 治疗的理想癌症。本综述阐明了 PDT 在 BCC 治疗中的临床应用中对研究人员的挑战。它概述了 PDT 的背景以及迄今为止如何开发用于 BCC 治疗的 PDT 治疗方法。各章节探讨了全身性 PDT 随后发展为局部 PDT 的过程，包括光敏剂、光传递方案的开发，以及 PDT 在不同患者人群和 BCC 亚型中的应用。还讨论了局部 PDT 的结果，并与其他替代疗法进行了比较，同时还考虑了局部 PDT 联合和辅助治疗的应用。其目的是总结 BCC 背景下的临床相关性，并揭示研究需求领域，最终促进 PDT 治疗的改进。
