肿瘤中进化新基因的表达
Expression of evolutionarily novel genes in tumors.
作者信息
Kozlov A P
机构信息
The Biomedical Center and Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
出版信息
Infect Agent Cancer. 2016 Jul 19;11:34. doi: 10.1186/s13027-016-0077-6. eCollection 2016.
The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new functions beneficial to organisms. It is suggested to consider the expression of evolutionarily young or novel genes in tumors as a new biological phenomenon, a phenomenon of TSEEN (tumor specifically expressed, evolutionarily novel) genes.
通过不同分子机制起源的进化上的新基因在肿瘤中表达。有时，进化上的新基因在肿瘤中的表达具有高度特异性。此外，许多人类肿瘤相关基因在灵长类谱系中的正选择表明它们参与了对生物体有益的新功能的起源。建议将肿瘤中进化上年轻或新的基因的表达视为一种新的生物学现象，即肿瘤特异性表达的进化新基因（TSEEN）现象。
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