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以双侧视网膜出血伴多发视网膜浸润为表现的慢性髓系白血病

Chronic Myeloid Leukaemia Presenting as Bilateral Retinal Haemorrhages with Multiple Retinal Infiltrates.

作者信息

Rane Priyanka Ramkrishna, Barot Rakesh K, Gohel Devadatta Jayantilal, Bhagat Nupur

机构信息

Registrar, Department of Ophthalmology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Hospital , Kalwa, India .

Associate Professor and Head of Department, Department of Ophthalmology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Hospital , Kalwa, India .

出版信息

J Clin Diagn Res. 2016 May;10(5):ND04-5. doi: 10.7860/JCDR/2016/18215.7822. Epub 2016 May 1.

Abstract

Chronic Myeloid Leukaemia (CML) causes retinopathy manifesting as venous dilation and tortuosity, perivascular sheathing, retinal haemorrhages, microaneurysms, cotton-wool spots and optic nerve infiltration. Retina is the most commonly involved intraocular structure in CML. However, retinal involvement is a rare form of presentation of CML and few cases have been reported. We report a case of CML presenting as unilateral sudden visual loss. Fundus showed multiple white centered retinal haemorrhages in both eyes with unilateral macular oedema. Blood work-up showed raised WBC count, high platelet count and low Haemoglobin. Cytological analysis of bone marrow biopsy confirmed Philadelphia chromosome. After a course of Imatinib, visual acuity improved and haemorrhages resolved with normalization of macular thickness. In our case, patient presented early, leading to early detection producing better visual prognosis. This highlights the importance of detailed hematological work up in patients with retinal involvement to rule out leukaemic retinopathy.

摘要

慢性髓性白血病(CML)可导致视网膜病变,表现为静脉扩张和迂曲、血管周围鞘膜形成、视网膜出血、微动脉瘤、棉絮斑和视神经浸润。视网膜是CML最常累及的眼内结构。然而,视网膜受累是CML一种罕见的表现形式,报道的病例很少。我们报告1例以单侧突然视力丧失为表现的CML病例。眼底检查显示双眼有多个以白色为中心的视网膜出血,伴有单侧黄斑水肿。血液检查显示白细胞计数升高、血小板计数高和血红蛋白降低。骨髓活检的细胞学分析证实存在费城染色体。经过一个疗程的伊马替尼治疗后,视力改善,出血消退,黄斑厚度恢复正常。在我们的病例中,患者就诊早,从而得以早期发现,产生了较好的视力预后。这凸显了对视网膜受累患者进行详细血液学检查以排除白血病性视网膜病变的重要性。

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本文引用的文献

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Ocular and orbital involvement in leukemia.白血病的眼部和眼眶受累情况。
Surv Ophthalmol. 1983 Jan-Feb;27(4):211-32. doi: 10.1016/0039-6257(83)90123-6.
8
Ophthalmic manifestations of leukemia.白血病的眼部表现
Arch Ophthalmol. 1989 May;107(5):697-700. doi: 10.1001/archopht.1989.01070010715033.

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